Popović D, Stanković-Popović V, Milosavljević T, Jovanović I, Pesko P, Simić A, Micev M, Milicić B, Kristić M
Institut za bolesti digestivnog sistema, Klinika za gastroenterologiju i hepatologiju, Klinicki centar Srbije.
Acta Chir Iugosl. 2006;53(3):41-8. doi: 10.2298/aci0603041p.
Gastro-oesophageal reflux disease (GERD) includes wide spectrum of symptoms caused by gastric acid regurgitation through the incompetent lower oesophageal sphincter in oesophagus. Etiopathogenesis of GERD is multifactorial.
to establish the relationship between Helicobacter pylori eradication and appearance or aggravating of present GERD. If this relationship exist, the aim is to estimate its level and clinical consequences.
50 Helicobacter pylori positive patients with different endoscopic findings (ulcer disease, gastritis and non-ulcer dyspepsia) to whom eradication of Helicobacter pylori was done, were following next 6 months. Questionnaire, uppear GI endoscopy with verification changes of oesophagus in accordance to LA classification, histopathological examination of gastric and oesophageal mucosal biopsy specimens, and oesophageal manometry have been done to all patients. These examinations have been done before Helicobacter pylori eradication and one, three. six and none months after that.
non statistical significant difference was found among the appearance or aggravating of present GERD in all patients during the following period (Cochran Q test; p=0,408). Non statistical significant difference was found among the endoscopic types of oesophagitis (LA classification) in all patients during the following 6 months (Friedman test; p=0,058). Non statistical significant difference was found among the changes of histopathological findings on distal oesophagus, too (Friedman test; p=0,217).
Eradication od Helicobacter pylori infection does not cause the appearance or aggravating of present GERD. The presence of mildly form of GERD, or aggravating of present GERD is transitory, and haven't the statistical signification.
胃食管反流病（GERD）包括因胃酸通过食管下括约肌功能不全反流至食管而引起的一系列症状。GERD的病因发病机制是多因素的。
确定根除幽门螺杆菌与现有GERD的出现或加重之间的关系。如果存在这种关系，则旨在评估其程度和临床后果。
对50例幽门螺杆菌阳性且有不同内镜检查结果（溃疡病、胃炎和非溃疡性消化不良）并已进行幽门螺杆菌根除治疗的患者，随访6个月。对所有患者进行问卷调查、上消化道内镜检查以根据洛杉矶分类法核实食管变化、胃和食管黏膜活检标本的组织病理学检查以及食管测压。这些检查在根除幽门螺杆菌之前以及之后1个月、3个月、6个月进行。
在随访期间，所有患者现有GERD的出现或加重之间未发现统计学显著差异（ Cochr an Q检验；p = 0.408）。在接下来的6个月中，所有患者食管炎的内镜类型（洛杉矶分类法）之间未发现统计学显著差异（Friedman检验；p = 0.058）。远端食管组织病理学结果的变化之间也未发现统计学显著差异（Friedman检验；p = 0.217）。
根除幽门螺杆菌感染不会导致现有GERD的出现或加重。轻度GERD的存在或现有GERD的加重是暂时的，且无统计学意义。
