Glaich Adrienne S, Rahman Zakia, Goldberg Leonard H, Friedman Paul M
DermSurgery Associates, Houston, Texas, TX 77030, USA.
Dermatol Surg. 2007 Mar;33(3):289-94; discussion 293-4. doi: 10.1111/j.1524-4725.2007.33058.x.
Treatments for hypopigmented scars have shown limited efficacy and variable safety profiles. OBJECTIVE This study evaluated the safety and efficacy of fractional resurfacing (1,550-nm Fraxel SR laser, Reliant Technologies, Mountain View, CA) for the treatment of hypopigmented scars on the face in seven patients.
Seven patients with hypopigmented scars on the face received between two and four successive treatments at 4-week intervals with the 1,550-nm Fraxel SR laser. Energy settings ranged from 7 to 20 mJ and a total density of 1,000 to 2,500 microthermal zones per square centimeter. Digital photographs were taken before each treatment and at 4 weeks after the last treatment. Independent physician clinical assessments were performed.
Independent physician clinical assessment 4 weeks after the final Fraxel SR laser treatment revealed improvements of 51% to 75% in hypopigmentation in six of seven patients. One patient had only 26% to 50% improvement in hypopigmentation. Additionally, clinical improvements were noted in the overall texture of the treated skin. The patient's degree of satisfaction paralleled the physician's assessment of improvement. All patients reported improvement in hypopigmentation lasting greater than 3 months after the last treatment. Side effects were limited to mild pain during the treatment and mild posttreatment erythema and edema, which resolved in 2 to 4 days.
Fractional resurfacing is a potentially effective modality for the treatment of hypopigmented scarring on the face. No adverse effects were observed.
色素减退性瘢痕的治疗效果有限,安全性也各不相同。目的:本研究评估了分次激光换肤(1550nm非剥脱性铒激光,Reliant Technologies公司,加利福尼亚州山景城)对7例面部色素减退性瘢痕的安全性和有效性。
7例面部色素减退性瘢痕患者接受了1550nm非剥脱性铒激光治疗,每隔4周连续治疗2至4次。能量设置范围为7至20mJ,每平方厘米的微热区总密度为1000至2500个。每次治疗前及最后一次治疗后4周拍摄数码照片。由独立的医生进行临床评估。
最后一次非剥脱性铒激光治疗4周后,独立医生的临床评估显示,7例患者中有6例色素减退改善了51%至75%。1例患者色素减退仅改善了26%至50%。此外,治疗皮肤的整体质地也有临床改善。患者的满意度与医生对改善情况的评估一致。所有患者均报告色素减退在最后一次治疗后持续改善超过3个月。副作用仅限于治疗期间的轻度疼痛以及治疗后的轻度红斑和水肿,在2至4天内消退。
分次激光换肤是治疗面部色素减退性瘢痕的一种潜在有效方法。未观察到不良反应。