肺动脉高压中的一氧化氮/cGMP信号通路。
The nitric oxide/cGMP signaling pathway in pulmonary hypertension.
作者信息
Klinger James R
机构信息
Division of Pulmonary Sleep and Critical Care Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.
出版信息
Clin Chest Med. 2007 Mar;28(1):143-67, ix. doi: 10.1016/j.ccm.2006.12.002.
PMID:17338933
Abstract
This article briefly reviews the background of endothelium-dependent vasorelaxation, describes the nitric oxide/cGMP/protein kinase pathway and its role in modulating pulmonary vascular tone and remodeling, and describes three approaches that target the nitric oxide/cGMP pathway in the treatment of patients with pulmonary arterial hypertension.
摘要
本文简要回顾了内皮依赖性血管舒张的背景，描述了一氧化氮/cGMP/蛋白激酶途径及其在调节肺血管张力和重塑中的作用，并介绍了在肺动脉高压患者治疗中靶向一氧化氮/cGMP途径的三种方法。
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