Ehara Shoichi, Yoshiyama Minoru
Osaka City University Graduate School of Medicine, Department of Internal Medicine and Cardiology.
Clin Calcium. 2007 Mar;17(3):325-31.
Calcification is a common finding in human coronary arteries, which is generally associated with long-standing atherosclerosis. However, there is conflicting evidence for the link between calcification and plaque instability. Recent histopathological studies have revealed that plaque calcification is present in 69% of ruptured plaques in sudden coronary death. Furthermore, studies using electron-beam computed tomography have reported that calcium score relates to acute coronary events. Recently, we clarified that in patients with acute myocardial infarction small "spotty" calcifications prevailed, associated with a fibrofatty plaque and positive remodeling. Future studies would focus on the clinical implication of coronary calcification.
钙化是人类冠状动脉中常见的现象，通常与长期存在的动脉粥样硬化相关。然而，关于钙化与斑块不稳定性之间的联系，证据存在矛盾。最近的组织病理学研究表明，在冠状动脉猝死的破裂斑块中，69%存在斑块钙化。此外，使用电子束计算机断层扫描的研究报告称，钙化积分与急性冠状动脉事件有关。最近，我们明确了在急性心肌梗死患者中，小的“斑点状”钙化较为普遍，与纤维脂肪斑块和阳性重塑相关。未来的研究将聚焦于冠状动脉钙化的临床意义。
