Yutani Chikao
Okayama University of Sience, Faculty of Sience, Department of Life Sience.
Clin Calcium. 2007 Mar;17(3):332-7.
Calcification is an invariable component of advanced coronary artery atherosclerosis. Recent study showed that genetic variations such as matrix inhibitory proteins, polymorphisms for tumor necrosis factor, and inflammatory cytokines may influence coronary artery calcification. And also there have been numerous studies on screening patients for coronary artery disease using electron beam computed tomography, but details of mechanism on calcification have still been unclear. An example of coronary calcification in diabetic patients disclosed that its diffuse distribution might be metabolic on calcification mechanism.
钙化是晚期冠状动脉粥样硬化的一个不变组成部分。最近的研究表明,诸如基质抑制蛋白、肿瘤坏死因子多态性和炎性细胞因子等基因变异可能影响冠状动脉钙化。并且已经有许多关于使用电子束计算机断层扫描筛查冠心病患者的研究,但钙化机制的细节仍不清楚。糖尿病患者冠状动脉钙化的一个例子表明,其弥漫性分布在钙化机制上可能是代谢性的。