[从正常细胞和肿瘤细胞中分离出的DNA的结构转变]
[Structural transitions in DNA, isolated from normal and neoplastic cells].
作者信息
Mil' E M, Bobovich S I, Azizov Iu M, Krinitskaia L A, Zhil'tsova V M
出版信息
Biofizika. 1975 Sep-Oct;20(5):757-61.
PMID:173399
Abstract
A decrease of temperature transition in spin-labeled DNA isolated from leucose cells compared with normal cells is found. It is shown by kinetic formaldehyde method that it may be the result of many defects in the secondary structure of macromolecule in DNA1. The spin label method is shown to be used for the analysis of DNA macromolecule damaged with small irradiation doses. Various radiosensitivity of DNA isolated from the blood of normal and leucose cells is observed.
摘要
与正常细胞相比，从白血病细胞中分离出的自旋标记DNA的温度转变有所降低。动力学甲醛法表明，这可能是DNA1大分子二级结构中许多缺陷的结果。自旋标记法被证明可用于分析受到小剂量辐射损伤的DNA大分子。观察到从正常和白血病细胞血液中分离出的DNA具有不同的放射敏感性。
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