Department of Chemistry, Higher Medical Institute, 4000 Ploviv, Bulgaria.
Planta Med. 1984 Apr;50(2):136-8. doi: 10.1055/s-2007-969652.
As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had not been detected in our initial study of the plant. The structure of buldodione was elucidated on the basis of spectral data and confirmed by synthesis of the alkaloid by means of Fremy's radical oxidation of bulbocapnine. The identification of the known alkaloids was obtained from their IR and (1)H-NMR spectral data and by direct comparison with authentic samples.
由于对保加利亚产紫堇属（罂粟科）植物紫堇块茎中的生物碱含量进行了重新研究，分离得到了一个新的 8,11-二氧阿朴啡类生物碱，命名为紫堇块茎酮，此外还分离得到了二氢血根碱、去氢血根碱、(+/-)-白屈菜碱、血根碱和刻叶紫堇灵。这些生物碱在我们最初对该植物的研究中并未检测到。根据光谱数据阐明了紫堇块茎酮的结构，并通过 Fremy 自由基氧化紫堇块茎碱合成该生物碱的方法进行了确证。通过与标准品的直接比较以及根据其 IR 和 (1)H-NMR 光谱数据，鉴定了已知的生物碱。
