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成人先天性心脏病的激光导线拔除术

Laser lead extraction in adult congenital heart disease.

作者信息

Khairy Paul, Roux Jean-François, Dubuc Marc, Thibault Bernard, Guerra Peter G, Macle Laurent, Mercier Lise-Andrée, Dore Annie, Roy Denis, Talajic Mario, Pagé Pierre

机构信息

Adult Congenital Heart Center, Montreal Heart Institute, Montreal, QC, Canada.

出版信息

J Cardiovasc Electrophysiol. 2007 May;18(5):507-11. doi: 10.1111/j.1540-8167.2007.00782.x. Epub 2007 Mar 6.

Abstract

BACKGROUND

In adults with congenital heart disease (ACHD), lead extraction procedures are expected to parallel increasing transvenous pacemaker and defibrillator implantations. We sought to assess the safety and feasibility of laser lead extraction in ACHD.

METHODS AND RESULTS

All laser lead extractions (Spectranectics, Colorado Springs, CO, USA) performed at the Montreal Heart Institute between September 2000 and August 2005 were prospectively registered. Efficacy and complications in patients with ACHD were compared to the larger cohort. Laser lead extraction was attempted on 270 leads in 175 patients. In ACHD, 23 (five atrial, 15 ventricular pacing, and three defibrillator) leads were targeted in 16 patients. Indications were: infection 44%, dysfunction 25%, upgrade 25%, and pain 6%. Patients with ACHD were younger (43.0 +/- 13.5 vs 63.7 +/- 14.7 years, P < 0.0001) and had a higher proportion of active fixation leads (74% vs 37%, P = 0.0013). Lead age in patients with and without ACHD was 9.0 +/- 5.2 vs 7.7 +/- 5.2 years (P = 0.2713). Overall, 21 of 23 leads (91%) were successfully extracted in ACHD compared with 220 of 247 leads (89%) (P = 0.7405). One major complication (6.3%) occurred in ACHD (tricuspid valve laceration) compared with five major (3.0%) and eight minor (5.0%) complications in patients without ACHD. Presence of ACHD did not modulate procedural success (OR 1.3, 95% CI [0.3, 5.8]) or complications (OR 1.0, 95% CI [0.2, 4.4]). Median procedural time was 27 minutes longer in ACHD (127 vs 100 minutes, P = 0.0595).

CONCLUSION

In selected patients with ACHD, laser lead extraction may be performed with a safety and efficacy profile comparable to patients without ACHD.

摘要

背景

在患有先天性心脏病的成人(ACHD)中,预计拔除导线的操作将随着经静脉起搏器和除颤器植入数量的增加而增多。我们旨在评估ACHD患者激光导线拔除术的安全性和可行性。

方法与结果

对2000年9月至2005年8月在蒙特利尔心脏研究所进行的所有激光导线拔除术(美国科罗拉多州斯普林斯市的Spectranectics公司产品)进行前瞻性登记。将ACHD患者的疗效和并发症与更大的队列进行比较。对175例患者的270根导线尝试进行激光导线拔除。在ACHD患者中,对16例患者的23根导线(5根心房导线、15根心室起搏导线和3根除颤器导线)进行了靶向治疗。适应证为:感染44%、功能障碍25%、升级25%和疼痛6%。ACHD患者更年轻(43.0±13.5岁对63.7±14.7岁,P<0.0001),主动固定导线的比例更高(74%对37%,P = 0.0013)。有和没有ACHD患者的导线使用时间分别为9.0±5.2年和7.7±5.2年(P = 0.2713)。总体而言,ACHD患者中23根导线中的21根(91%)成功拔除,而在非ACHD患者中247根导线中的220根(89%)成功拔除(P = 0.7405)。ACHD患者发生1例主要并发症(6.3%)(三尖瓣撕裂),而非ACHD患者发生5例主要并发症(3.0%)和8例次要并发症(5.0%)。ACHD的存在并未影响手术成功率(比值比1.3,95%置信区间[0.3, 5.8])或并发症发生率(比值比1.0,95%置信区间[0.2, 4.4])。ACHD患者的手术中位时间长27分钟(127分钟对100分钟,P = 0.0595)。

结论

在选定的ACHD患者中,激光导线拔除术的安全性和有效性与非ACHD患者相当。

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