脂联素作为一种抗炎因子。
Adiponectin as an anti-inflammatory factor.
作者信息
Ouchi Noriyuki, Walsh Kenneth
机构信息
Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA.
出版信息
Clin Chim Acta. 2007 May 1;380(1-2):24-30. doi: 10.1016/j.cca.2007.01.026. Epub 2007 Feb 2.
Obesity is characterized by low-grade systemic inflammation. Adiponectin is an adipose tissue-derived hormone, which is downregulated in obesity. Adiponectin displays protective actions on the development of various obesity-linked diseases. Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. In this review, we focus on the role of adiponectin in regulation of inflammatory response and discuss its potential as an anti-inflammatory marker.
肥胖的特征是低度全身性炎症。脂联素是一种源自脂肪组织的激素，在肥胖状态下其表达下调。脂联素对多种与肥胖相关疾病的发展具有保护作用。多项临床研究表明，血浆脂联素水平与包括C反应蛋白在内的多种炎症标志物呈负相关。脂联素通过调节多种细胞类型中的信号通路来减轻对多种刺激的炎症反应。脂联素的抗炎特性可能是其对心血管和代谢紊乱（包括动脉粥样硬化和胰岛素抵抗）产生有益作用的主要组成部分。在本综述中，我们重点关注脂联素在调节炎症反应中的作用，并讨论其作为抗炎标志物的潜力。
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