Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China.
Vitam Horm. 2012;90:375-95. doi: 10.1016/B978-0-12-398313-8.00014-2.
Numerous lines of evidence implicate a role for adipose tissue in the development of a systemic inflammatory state that contributes to metabolic, cardiovascular, and autoimmune disorders. Serum levels of adiponectin, a cytokine that is mainly produced by adipocytes, are paradoxically decreased in individuals with obesity, type 2 diabetes, and cardiovascular disease compared with healthy individuals. Mounting experimental data have revealed that adiponectin exhibits beneficial effects on energy homeostasis and cardiovascular functions that are attributed to its direct modulation of a proinflammatory factor, interleukin-6. However, some recent studies indicate that adiponectin appears to function as an inducer of proinflammatory factors and the elevated adiponectin level aggravates inflammation response in autoimmune disease. In this review, we focus on the action of adiponectin in chronic inflammation-associated metabolic, cardiovascular, and autoimmune disorders. In particular, we discuss the interaction between adiponectin and interleukin-6 in adipocytes and cardiovascular cells.
大量证据表明脂肪组织在全身性炎症状态的发展中起作用，这种炎症状态导致代谢、心血管和自身免疫性疾病。与健康个体相比，肥胖症、2 型糖尿病和心血管疾病患者的血清脂联素水平降低，脂联素是一种主要由脂肪细胞产生的细胞因子。越来越多的实验数据表明，脂联素对能量平衡和心血管功能具有有益的影响，这归因于其对促炎因子白细胞介素-6的直接调节。然而，一些最近的研究表明，脂联素似乎作为促炎因子的诱导剂发挥作用，并且在自身免疫性疾病中升高的脂联素水平加重炎症反应。在这篇综述中，我们重点关注脂联素在与慢性炎症相关的代谢、心血管和自身免疫性疾病中的作用。特别是，我们讨论了脂联素和白细胞介素-6在脂肪细胞和心血管细胞中的相互作用。
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