Jacobi Shimshon, Moses Elisha
Department of Physics of Complex Systems, The Weizmann Institute of Science, P.O. Box 26, Rehovot 76100, Israel.
J Neurophysiol. 2007 May;97(5):3597-606. doi: 10.1152/jn.00608.2006. Epub 2007 Mar 7.
We investigate the propagation of neural activity along one-dimensional rat hippocampal cultures patterned in lines over multielectrode arrays. Activity occurs spontaneously or is evoked by local electrical or chemical stimuli, with different resulting propagation velocities and firing rate amplitudes. A variability of an order of magnitude in velocity and amplitude is observed in spontaneous activity. A linear relation between velocity and amplitude is identified. We define a measure for neuron activation synchrony and find that it correlates with front velocity and is higher for electrically evoked fronts. We present a model that explains the linear relation between amplitude and velocity, which highlights the role of synchrony. The relation to current models for signal propagation in neural media is discussed.
我们研究了神经活动在一维大鼠海马体培养物中的传播情况，这些培养物在多电极阵列上呈线状排列。活动自发产生，或由局部电刺激或化学刺激诱发，产生不同的传播速度和放电率幅度。在自发活动中观察到速度和幅度有一个数量级的变化。确定了速度与幅度之间的线性关系。我们定义了一种神经元激活同步性的测量方法，发现它与前沿速度相关，并且在电诱发前沿时更高。我们提出了一个模型来解释幅度与速度之间的线性关系，该模型突出了同步性的作用。还讨论了与当前神经介质中信号传播模型的关系。
