Fisher E R, Gregorio R M, Fisher B, Redmond C, Vellios F, Sommers S C
Cancer. 1975 Jul;36(1):1-85. doi: 10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4.
The inter-relationships of 32 pathologic and 7 clinical parameters encountered in the study of 1000 examples of invasive breast carcinoma have been presented. In some instances the biological significance of these associations is at present unclear. In others it is to be noted that there is no information provided as to the rank of their significance. Nevertheless, the associations that were encountered not only help further characterize the various forms of breast cancer but also provide information regarding the possible biological significance of some of their features. Although it is not our intention to minimize the possible significance of the inter-relationships of pathologic parameters, most emphasis in the summarizing statements which follow has been placed upon those correlations which may relate to prognosis. In this regard reference has been made to short-term treatment failure, vis a vis local recurrence and/or metastases, which may not necessarily accurately reflect patient survival, although generally such a relationship exists. Information in this regard as well as to the rank of the significance of these pathologic features shall be forthcoming when sufficient time has elapsed since the inception of this study to allow for such conclusions, i.e. survival or long-term treatment failure rates. Lastly, it becomes evident that the guidelines followed in the examination of these specimens appear to represent at least the minimum requirements necessary for a meaningful pathologic evaluation of breast carcinoma.
本文呈现了在1000例浸润性乳腺癌研究中所遇到的32个病理参数与7个临床参数之间的相互关系。在某些情况下，这些关联的生物学意义目前尚不清楚。在其他情况下，需要注意的是，文中并未提供关于它们重要性排序的信息。然而，所遇到的这些关联不仅有助于进一步刻画乳腺癌的各种形式，还能提供有关其某些特征可能具有的生物学意义的信息。虽然我们无意低估病理参数相互关系的可能重要性，但在后续的总结陈述中，重点主要放在了那些可能与预后相关的相关性上。在这方面，我们提到了短期治疗失败，即相对于局部复发和/或转移而言，尽管通常存在这种关系，但这不一定能准确反映患者的生存情况。当自本研究开始以来经过足够长的时间以得出此类结论，即生存率或长期治疗失败率时，关于这方面的信息以及这些病理特征重要性的排序将会得出。最后，显而易见的是，在检查这些标本时所遵循的指导原则似乎至少代表了对乳腺癌进行有意义的病理评估所需的最低要求。
