Liu Xiao-ping, Wang Yong, Qin Da-nian
Department of Physiology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Zhonghua Nan Ke Xue. 2007 Feb;13(2):171-4.
It has been demonstrated that insulin-like growth factor-1 (IGF-1) stimulates the proliferation and division of cells, facilitates the individual growth and development and regulates the material metabolism. Furthermore, it regulates male reproductive development and testicular endocrine functions. IGF-1 can stimulate the expression of GnRH gene in the hypothalamus of prepubertal male mice. However, it has no effect on or even inhibits GnRH gene expression in adult mice. IGF-1 may influence the growth, maturation and differentiation of GnRH neurons. It also accelerates LH and FSH secretion in hypophysis. IGF-1, produced locally in the testis and combined with its specific receptor, can regulate the proliferation and differentiation of adult Leydig cells, cause Sertoli cells to play different functions and control the biosynthesis of testicular hormones.
已证实胰岛素样生长因子-1（IGF-1）可刺激细胞的增殖和分裂，促进个体生长发育并调节物质代谢。此外，它还调节雄性生殖发育和睾丸内分泌功能。IGF-1可刺激青春期前雄性小鼠下丘脑GnRH基因的表达。然而，它对成年小鼠的GnRH基因表达没有影响甚至有抑制作用。IGF-1可能影响GnRH神经元的生长、成熟和分化。它还可加速垂体促黄体生成素（LH）和促卵泡生成素（FSH）的分泌。在睾丸局部产生并与其特异性受体结合的IGF-1，可调节成年睾丸间质细胞的增殖和分化，使支持细胞发挥不同功能并控制睾丸激素的生物合成。
