Liang Qiren, Zhang Jiyong, Quan Weiguo, Sun Yongquan, She Xuegong, Pan Xinfu
Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.
J Org Chem. 2007 Mar 30;72(7):2694-7. doi: 10.1021/jo070159v. Epub 2007 Mar 9.
The first efficient asymmetric total syntheses of xestodecalactones B and C have been accomplished in 10 steps with an overall yield of 22 and 20.2%, respectively. The key steps involve the utility of Evans oxazolidinone-mediated syn-aldol condensations to establish the C-9 configuration and the macrolide ring formation by intramolecular acylation. The absolute configurations of xestodecalactones B and C have been determined via these syntheses.
西托内酯B和C的首次高效不对称全合成已通过10步反应完成，总产率分别为22%和20.2%。关键步骤包括利用埃文斯恶唑烷酮介导的顺式羟醛缩合反应来构建C-9构型，以及通过分子内酰化反应形成大环内酯环。通过这些合成确定了西托内酯B和C的绝对构型。
