Hattori Yoshihide, Kurihara Kei, Kondoh Hirofumi, Asano Tomoyuki, Kirihata Mitsunori, Yamaguchi Yoshihiro, Wakamiya Tateaki
Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Protein Pept Lett. 2007;14(3):269-72. doi: 10.2174/092986607780090856.
Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.
硼中子俘获疗法（BNCT）和磁共振成像（MRI）分别是用于癌症治疗和诊断的极具吸引力的技术。为了开发同时用于BNCT和MRI的实用材料，已经设计并合成了氟化对硼苯丙氨酸及其醇衍生物。在本文中，对这些化合物的细胞毒性、进入癌细胞的量以及肿瘤细胞杀伤作用进行了阐明，以评估它们作为硼载体的实用性。
