番石榴叶水提取物对大鼠主动脉环的收缩作用。
Contractile effect of the aqueous extract of Psidium guajava leaves on aortic rings in rat.
作者信息
Olatunji-Bello I I, Odusanya A J, Raji I, Ladipo C O
机构信息
Department of Physiology, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.
出版信息
Fitoterapia. 2007 Apr;78(3):241-3. doi: 10.1016/j.fitote.2006.11.007. Epub 2007 Feb 6.
Aqueous leaves extract of Psidium guajava significantly and dose-dependently (0.25-2 mg/ml) contracted aorta rings. The effect was evaluated also in presence of nifedipine and phentolamine. The sensitivity of the aortic rings to cumulative doses of P. guajava was significantly enhanced in the presence of phentolamine suggesting that the effect of P. guajava was to a large extent mediated by activation of alpha-adrenoceptor and to a lesser extent by acting via calcium ion channel.
番石榴水叶提取物能显著且呈剂量依赖性地（0.25 - 2毫克/毫升）使主动脉环收缩。该效应也在硝苯地平和酚妥拉明存在的情况下进行了评估。在酚妥拉明存在的情况下，主动脉环对番石榴累积剂量的敏感性显著增强，这表明番石榴的作用在很大程度上是通过α - 肾上腺素能受体的激活介导的，而通过钙离子通道起作用的程度较小。
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