利用有机催化去对称化和光诱导碎片化对（+）-保幼酮进行对映体和非对映体控制的合成。
Enantio- and diastereo-controlled synthesis of (+)-juvabione employing organocatalytic desymmetrization and photoinduced fragmentation.
作者信息
Itagaki Noriaki, Iwabuchi Yoshiharu
机构信息
Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan.
出版信息
Chem Commun (Camb). 2007 Mar 12(11):1175-6. doi: 10.1039/b616641e. Epub 2007 Jan 9.
DOI:10.1039/b616641e
PMID:17347730
Abstract
(+)-Juvabione, a natural sesquiterpene exhibiting insect juvenile hormone activity, has been synthesized from sigma-symmetric 4-(2-formyl-ethyl)cyclohexanone by employing organocatalytic asymmetric aldolization and Norrish I-type fragmentation as the key steps.
摘要
(+)-珠蝽二烯酮是一种具有昆虫保幼激素活性的天然倍半萜烯，它以σ-对称的4-(2-甲酰基乙基)环己酮为原料，采用有机催化不对称羟醛缩合反应和Norrish I型裂解反应作为关键步骤合成得到。
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