Vrielynck Freek A, De Clercq Pierre J
Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 (S4), B-9000 Gent, Belgium.
Molecules. 2007 Feb 21;12(2):237-44. doi: 10.3390/12020237.
The asymmetric rhodium-catalysed 1,4-addition of alkenylzirconium reagents to 2-cyclohexenone can be useful in the synthesis of 3-alkenyl-2-methylcyclohexanones, provided that formaldehyde is used in trapping the intermediate zirconium enolates. In this manner a four-step sequence leading to the two epimeric 3-hexenyl-2-methylcyclohexanones in enantiomeric form was developed.
在2-环己烯酮的不对称铑催化的链烯基锆试剂的1,4-加成反应中，只要使用甲醛捕获中间体锆烯醇盐，该反应对于3-链烯基-2-甲基环己酮的合成可能是有用的。通过这种方式，开发了一种四步反应序列，可得到对映体形式的两种差向异构的3-己烯基-2-甲基环己酮。
