Lee Amie Y, Raz Dan J, He Biao, Jablons David M
Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, California 94143, USA.
Cancer. 2007 Apr 15;109(8):1454-61. doi: 10.1002/cncr.22552.
Malignant mesothelioma (MM) is a highly aggressive tumor with a very poor prognosis. The disease is largely unresponsive to conventional chemotherapy or radiotherapy, and most patients die within 10-17 months of the first symptoms. Novel, more effective therapeutic strategies are needed for this inexorably fatal disease. Improvement in our understanding of the molecular biology of MM has identified promising new candidates for targeted treatments. In this review the key molecular signaling pathways, including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), Wnt, and the cell cycle control genes p53, pRb, and bcl-2 that appear to play an important role in the pathogenesis of MM are explored.
恶性间皮瘤（MM）是一种侵袭性很强且预后极差的肿瘤。该疾病对传统化疗或放疗大多无反应，大多数患者在出现首发症状后的10 - 17个月内死亡。对于这种必然致命的疾病，需要新的、更有效的治疗策略。我们对MM分子生物学认识的提高已经确定了有前景的新的靶向治疗候选物。在这篇综述中，探讨了关键的分子信号通路，包括血管内皮生长因子（VEGF）、表皮生长因子（EGF）、Wnt以及细胞周期调控基因p53、pRb和bcl - 2，这些通路似乎在MM的发病机制中起重要作用。
