Zhang Li, Gao Si-Hua, Zhou Chao-fan, Lin Rui-chao, Liu Chang-hua
Center or Drug reevaluation, State Food and Drug Administration, Beijing 100061, China.
Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(23):2010-3.
By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety problems of Niuhuang Jiedu Pian (Wan) and other traditional Chinese medicine (TCM) preparations containing arsenic substances. In this article we also put forward suggestions for strengthening the surveillance and administration of similar TCM preparations.
通过全面回顾牛黄解毒丸及其“衍生制剂”的起源和历史，我们研究了雄黄的临床记录，查阅文献探讨其临床用法、用量、疗效及毒性。我们明确了可能与牛黄解毒片（丸）及其他含砷类中药制剂安全性问题相关的因素。本文还就加强此类中药制剂的监测与管理提出了建议。
