Rudenko Ia N, Bigdaĭ E V, Samoĭlov V O
Biofizika. 2007 Jan-Feb;52(1):88-94.
The kinetics of fluorescence of Ca(2+) - chlortertacyclin-cell membrane complex as well as of NADH and oxidized flavoproteins in receptor cells of the frog olfactory lining under the effect of odorants has been studied. Changes in the fluorescence of the olfactory lining upon stimulation by cineole and vanillin occurred more rapidly than under the effect of camphor and amyl alcohol. Differences in the kinetics of reactions of NADH and the Ca(2+)-CTC-CM complex to different odorants are apparently due to heterogeneity of molecular mechanisms associated with the involvement of different intracellular signal systems in the transduction of these odorants in the olfactory lining. In contrast to them, ammonia and beta3-mercaptoethanol penetrate into olfactory cells and inhibit the mitochondrial respiratory chain without the participation of second messengers. At the same time, the motor activity of olfactory cilia is depressed.
研究了在气味剂作用下，蛙嗅觉上皮受体细胞中Ca(2+) - 氯四环素 - 细胞膜复合物以及NADH和氧化黄素蛋白的荧光动力学。由桉叶油素和香草醛刺激引起的嗅觉上皮荧光变化比樟脑和戊醇作用下发生得更快。NADH和Ca(2+) - CTC - CM复合物对不同气味剂反应的动力学差异显然是由于与不同细胞内信号系统参与这些气味剂在嗅觉上皮中的转导相关的分子机制的异质性。与它们不同的是，氨和β3 - 巯基乙醇可穿透嗅觉细胞并抑制线粒体呼吸链，且无需第二信使的参与。与此同时，嗅觉纤毛的运动活性受到抑制。
