Mai G T, Choo E, Yang J L, Cooke B, Dumitru D, Lonergan D, Lewis C R
Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD 4102.
Anticancer Res. 2007 Jan-Feb;27(1B):647-52.
Breast conservation therapy (BCT) is recommended as standard management of early breast cancer. The aim of this study was to retrospectively evaluate the results of BCT to identify prognostic factors predictive of treatment outcomes.
Four hundred and ninety-eight eligible women with unilateral stage I-II breast cancer who had undergone BCT were analyzed.
The cumulative incidence of local recurrence (LR) was 1.9% and 3.7% at 3- and 5-years respectively. The 5-year disease-free, cancer-specific, and overall survival (DFS, CSS, OS) were 80.0%, 87.3% and 85.4% respectively. Significant independent predictors for LR included young age and absence of chemotherapy. Regional nodal radiotherapy was significantly associated with improved DFS and OS.
Our results confirmed the efficacy of BCT in the treatment of early breast cancer and indicated that inclusion of regional nodal areas within the radiotherapy field might be beneficial in the BCT setting, particularly for patients with adverse risk features.
保乳治疗（BCT）被推荐作为早期乳腺癌的标准治疗方法。本研究的目的是回顾性评估保乳治疗的结果，以确定预测治疗效果的预后因素。
分析了498例接受保乳治疗的单侧I-II期乳腺癌合格女性。
局部复发（LR）的3年和5年累积发生率分别为1.9%和3.7%。5年无病生存率、癌症特异性生存率和总生存率（DFS、CSS、OS）分别为80.0%、87.3%和85.4%。LR的显著独立预测因素包括年轻和未接受化疗。区域淋巴结放疗与DFS和OS的改善显著相关。
我们的结果证实了保乳治疗在早期乳腺癌治疗中的疗效，并表明在保乳治疗中，将区域淋巴结区域纳入放疗野可能有益，特别是对于具有不良风险特征的患者。
