Goeb Katja, Engehausen Dirk G, Krause F Steffen, Hollenbach Hans-Peter, Niedobitek Gerald, Buettner Maike, Frangou Phroso, Engelhard Karl
Department of Radiology, Martha-Maria Hospital, Nuremberg, Germany.
Anticancer Res. 2007 Jan-Feb;27(1B):687-93.
The purpose of this study was to evaluate the suitability of MR Spectroscopy in screening for prostate cancer in comparison to T2-weighted MR imaging.
Forty-six patients with biopsy confirmed prostate cancer underwent combined endorectal-body-phased-array MRI at 1.5T (Tesla). Twelve patients were additionally examined with 3D-spectroscopy sequence. The results of the spectroscopy were compared with the findings of T2-weighted MR imaging and the histological examination of radical prostatectomy specimens.
With 3D-spectroscopy, a choline+creatine/citrate-ratio of 0.45 for healthy tissue and a ratio of 1.90 for tumor tissue were found and a significant difference between the groups was demonstrated. In 6 cases diagnosis of tumor localization was improved with spectroscopy in comparison with T2-weighted imaging alone.
3D-spectroscopy is a suitable technique for improving MR imaging of prostate cancer. This method can improve the diagnostic accuracy of T2-weighted imaging alone. At present, 3D-CSI spectroscopy alone can not be recommended with sufficient validity.
本研究的目的是评估磁共振波谱成像与T2加权磁共振成像相比在前列腺癌筛查中的适用性。
46例经活检证实为前列腺癌的患者接受了1.5T（特斯拉）的直肠内体部相控阵联合磁共振成像检查。另外12例患者接受了三维波谱序列检查。将波谱成像结果与T2加权磁共振成像结果以及前列腺癌根治术标本的组织学检查结果进行比较。
通过三维波谱成像，发现健康组织的胆碱+肌酸/枸橼酸盐比值为0.45，肿瘤组织的比值为1.90，两组之间存在显著差异。与单纯T2加权成像相比，有6例通过波谱成像改善了肿瘤定位诊断。
三维波谱成像是一种改善前列腺癌磁共振成像的合适技术。该方法可以提高单纯T2加权成像的诊断准确性。目前，仅三维化学位移成像波谱法的有效性不足以推荐使用。
