Mizutani R, Shimada I, Ueno Y, Yoda M, Kumagai H, Arata Y
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biochem Biophys Res Commun. 1992 Jan 31;182(2):966-73. doi: 10.1016/0006-291x(92)91826-c.
Solution conformations of cyclo(GRGDSPA) have been analyzed by the use of two-dimensional proton nuclear magnetic resonance spectroscopy and the dynamical simulated annealing calculation. It has been shown that the RGDS segment in cyclo(GRGDSPA) takes a beta-turn conformation. We have concluded that this beta-turn conformation is essential for the physiological activity of cyclo(GRGDSPA).
通过二维质子核磁共振光谱法和动态模拟退火计算，对环（GRGDSPA）的溶液构象进行了分析。结果表明，环（GRGDSPA）中的RGDS片段呈β-转角构象。我们得出结论，这种β-转角构象对环（GRGDSPA）的生理活性至关重要。
