Bhoga Umadevi
Organic Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Eur J Med Chem. 2007 Aug;42(8):1144-50. doi: 10.1016/j.ejmech.2007.01.016. Epub 2007 Jan 27.
A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2'-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC(50)=4.84x10(-7)M.
描述了一种使用介孔硅铝酸盐催化剂HMCM-41合成N-芳基-4-(3-吡啶基)噻唑-2-胺及其类似物的新方法，以及它们对人血小板的体外ADP诱导的血小板聚集抑制活性。在测试化合物中，N-(2'-氟苯基)-4-(3-吡啶基)噻唑-2-胺(9e)被发现是最有效的，IC(50)=4.84x10(-7)M。
