She Jun, Sun Qingyi, Fan Lihong, Qin Huanlong, Bai Chunxue, Shen Ce
Department of Respiratory Medicine, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, 600 Yi Shan Road, Shanghai 200233, PR China.
Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):366-73. doi: 10.1016/j.resp.2007.01.018. Epub 2007 Feb 4.
Diffuse panbronchiolitis (DPB) is a pulmonary disease of unknown etiology that predominantly affects East Asians, particularly Japanese with a prevalence of 0.00028. Research has shown that HLA-B54 and HLA-A11 are positively associated with this disease. HLA-A, -B, and -DR loci were analyzed using an oligonucleotide microarray in both Chinese patients with DPB and normal control subjects. The most marked difference between the patients and the controls was the decreased frequency of HLA-A2 (p=0.001, OR=0.12), which showed a negative association with the disease; however, there was no significant contribution of HLA-B loci. Interestingly, the frequency of HLA-A11 was increased (p=0.007, OR=3.9), in accordance with previous reports on Japanese and Koreans. In addition, the frequency of HLA-DRB5*010/020 slightly increased (p=0.049). The HLA-associated genes for DPB are located between the HLA-A and HLA-B loci. Differences in HLA-associated genes may partially explain differences in the incidence of DPB among different populations.
弥漫性泛细支气管炎（DPB）是一种病因不明的肺部疾病，主要影响东亚人，尤其是日本人，患病率为0.00028。研究表明，HLA - B54和HLA - A11与该疾病呈正相关。使用寡核苷酸微阵列对中国DPB患者和正常对照受试者的HLA - A、 - B和 - DR位点进行了分析。患者与对照之间最显著的差异是HLA - A2频率降低（p = 0.001，OR = 0.12），这表明其与疾病呈负相关；然而，HLA - B位点没有显著作用。有趣的是，HLA - A11的频率增加（p = 0.007，OR = 3.9），这与之前关于日本人和韩国人的报道一致。此外，HLA - DRB5*010/020的频率略有增加（p = 0.049）。DPB的HLA相关基因位于HLA - A和HLA - B位点之间。HLA相关基因的差异可能部分解释了不同人群中DPB发病率的差异。
