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[腮腺复发性多形性腺瘤——治疗与结果]

[Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome].

作者信息

Nazarian Yaron, Talmi Yoav P, Wolf Michael, Horowitz Zeev, Bedrin Lev, Pfeffer Rephael, Kronenberg Jona

机构信息

Department of Oral and Maxillofacial Surgery, Barzilai Medical Center, Ashkelon, Israel.

出版信息

Harefuah. 2007 Feb;146(2):82-4, 168.

Abstract

Epithelial tumors of the parotid gland comprise 3% of head and neck tumors, and 70%-80% of those are benign. Pleomorphic adenoma is the most common tumor of the parotid gland. Recurrence rate of pleomorphic adenomas (RPAs) following superficial parotidectomy was reported to be as high as 4%, sometimes associated with inadequate surgical treatment of the primary tumor. These tumors have a very slow growth rate, and a ten-year follow-up period is mandatory. RPAs are usually located in the superficial lobe (75%) and are often multinodular. Treatment of RPAs is challenging due to a high risk of facial nerve paresis (7%-50%) and of re-recurrence. Occasionally, post-operative radiotherapy is indicated, but this treatment must be balanced with potential long term risks of secondary malignancy. Medical records of 16 patients with first recurrence and 4 patients with more than one recurrence who were treated in our institution during the past 5 years were reviewed. Five patients were treated by post-operative radiotherapy. Residual or recurrence rate following a second procedure was 15%. Two patients (10%) had permanent paresis of a single branch of the facial nerve. Seventeen out of 20 patients (85%) treated were disease-free after a follow-up period of 5 years. In conclusion, surgical treatment of RPAs is a complex procedure which should be managed by a trained surgical team and can be performed with success and minimal morbidity.

摘要

腮腺上皮性肿瘤占头颈部肿瘤的3%,其中70%-80%为良性。多形性腺瘤是腮腺最常见的肿瘤。据报道,腮腺浅叶切除术后多形性腺瘤的复发率高达4%,有时与原发肿瘤手术治疗不充分有关。这些肿瘤生长非常缓慢,必须进行十年的随访。多形性腺瘤通常位于浅叶(75%),且常为多结节性。由于面神经麻痹(7%-50%)和再次复发的风险较高,多形性腺瘤的治疗具有挑战性。偶尔需要术后放疗,但这种治疗必须与继发恶性肿瘤的潜在长期风险相权衡。回顾了我院过去5年收治的16例首次复发和4例多次复发患者的病历。5例患者接受了术后放疗。二次手术后的残留或复发率为15%。2例患者(10%)出现单支面神经永久性麻痹。20例接受治疗的患者中有17例(85%)在5年随访期后无疾病。总之,多形性腺瘤的手术治疗是一个复杂的过程,应由训练有素的手术团队进行管理,并且可以成功实施,并发症最少。

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