Zhang Qin, Qiu Hong, Wang Lei, DU Guang-li, Liu Ping
Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Zhong Xi Yi Jie He Xue Bao. 2007 Mar;5(2):130-3. doi: 10.3736/jcim20070205.
To investigate the pathological factors of syndrome pathomechanism through studying the correlation between syndromes of posthepatitic cirrhosis and biological parameters.
Clinical information of three hundred and fifty-five patients with posthepatitic cirrhosis was collected and the database was established. Parameters with statistical significance were analyzed with multi-factor regression analysis to investigate the main influencing factors of the syndromes of posthepatitic cirrhosis.
Formulae of six syndromes, including syndrome of yin deficiency of liver and kidney, syndrome of damp heat, syndrome of stagnated heat smoldering, syndrome of yang deficiency of spleen and kidney, syndrome of stagnation of liver qi and spleen deficiency and syndrome of blood stasis due to qi deficiency, were established with stepwise regression analysis.
One of the pathophysiological bases of syndrome of blood stasis due to qi deficiency in cirrhosis is synthetic dysfunction of hepatocytes. The pathophysiological basis of syndrome of damp heat is inflammatory injury, which is also syndrome of stagnated heat smoldering in cirrhosis patients. The relationship between syndrome of yin deficiency of liver and kidney and stasis and damp heat may be the pathophysiological basis of the posthepatitic cirrhosis..
通过研究肝炎后肝硬化证候与生物学参数之间的相关性，探讨证候病机的病理因素。
收集355例肝炎后肝硬化患者的临床资料并建立数据库。对具有统计学意义的参数进行多因素回归分析，以探讨肝炎后肝硬化证候的主要影响因素。
通过逐步回归分析建立了肝肾阴虚证、湿热证、肝郁化火证、脾肾阳虚证、肝郁脾虚证和气虚血瘀证六种证候的公式。
肝硬化气虚血瘀证的病理生理基础之一是肝细胞合成功能障碍。湿热证的病理生理基础是炎症损伤，这也是肝硬化患者的肝郁化火证。肝肾阴虚证与瘀血、湿热之间的关系可能是肝炎后肝硬化的病理生理基础。
