柴苓汤和防己地黄汤可改善由N-甲基-L-精氨酸甲酯诱导的子痫前期大鼠的高血压。

The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nomega-Nitro-L-arginine methyl ester.

作者信息

Takei Hisato, Nakai Yoichiro, Hattori Naoko, Yamamoto Masahiro, Takeda Shuichi, Yamamoto Masako, Arishima Kazuyoshi

机构信息

Pharmacology Research Department, Tsumura Research Institute, Tsumura and Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.

出版信息

Phytomedicine. 2007 Sep;14(9):591-600. doi: 10.1016/j.phymed.2007.01.009. Epub 2007 Mar 13.

DOI:10.1016/j.phymed.2007.01.009

PMID:17353120

Abstract

The chronic inhibition of nitric oxide (NO) synthesis with N(omega)-Nitro-L-arginine methyl ester (L-NAME) induces a pre-eclampsia-like syndrome including hypertension in pregnant rats. We tested the traditional herbal medicines Saireito (SR) and Boiogito (BO), which have been used clinically for the treatment of pre-eclampsia, in this model. L-NAME was infused subcutaneously into pregnant rats from gestational day 14 (G14). SR and BO (both at 1, 2g/kg) were administered by gavage from G14 to G20. Systolic blood pressure was measured on G19. SR and BO (both at 1, 2g/kg) inhibited L-NAME-induced hypertension. SR was effective in both pregnant and non-pregnant rats while BO was effective only in pregnant rats. BO increased blood levels of CGRP and decreased levels of endothelin-1; both are known to play important roles in regulation of blood pressure in pre-eclampsia. SR and BO may be beneficial for the treatment and prevention of hypertension in pre-eclampsia.

摘要

用N（ω）-硝基-L-精氨酸甲酯（L-NAME）长期抑制一氧化氮（NO）合成可在妊娠大鼠中诱发包括高血压在内的子痫前期样综合征。我们在此模型中测试了临床上用于治疗子痫前期的传统草药柴苓汤（SR）和补中益气汤（BO）。从妊娠第14天（G14）开始，将L-NAME皮下注射到妊娠大鼠体内。从G14至G20，通过灌胃给予SR和BO（均为1、2g/kg）。在G19测量收缩压。SR和BO（均为1、2g/kg）均可抑制L-NAME诱导的高血压。SR对妊娠和非妊娠大鼠均有效，而BO仅对妊娠大鼠有效。BO可提高降钙素基因相关肽（CGRP）的血药浓度并降低内皮素-1的浓度；已知二者在子痫前期血压调节中均起重要作用。SR和BO可能有助于子痫前期高血压的治疗和预防。