Suzuki Satoko, Obara Taku, Ishikawa Tomofumi, Noda Aoi, Matsuzaki Fumiko, Arita Ryutaro, Ohsawa Minoru, Mano Nariyasu, Kikuchi Akiko, Takayama Shin, Ishii Tadashi
Department of Education and Support for Regional Medicine, Tohoku University Hospital, Sendai, Japan.
Department of Kampo Medicine, Tohoku University Hospital, Sendai, Japan.
Front Nutr. 2021 Nov 12;8:762895. doi: 10.3389/fnut.2021.762895. eCollection 2021.
Traditional Japanese (Kampo) medicines are often prescribed for women in Japan before, during, and after pregnancy. However, detailed information on the actual frequency of use and safety of Kampo preparations during pregnancy is lacking. To investigate the frequency of prescription of Kampo medicines for pregnant women in Japan. Information on Kampo medicines prescribed during outpatient care and hospitalization of selected mothers from January 2005 to August 2016 were extracted from the Japan Medical Data Center (Tokyo, Japan), which is a large claims database. Of the 33,941 subscribers identified from the database, 16,294 (48%) received at least one prescription of a Kampo medicine. Kakkonto was the formula most prescribed during the study period, followed by shoseiryuto and tokishakuyakusan. In the 180 days before pregnancy, the most prescribed medicine was tokishakuyakusan, followed by kakkonto and shoseiryuto. Shoseiryuto, tokishakuyakusan, and kakkonnto were the formulae most prescribed during pregnancy. The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito. Information in the Japanese insurance system shows that Kampo medicines are often prescribed during pregnancy. Most of these prescriptions are generally used for the treatment of common cold. Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan.
在日本，传统的汉方药常用于女性孕期、产前及产后。然而，关于汉方制剂在孕期的实际使用频率及安全性的详细信息却很匮乏。为调查日本孕妇使用汉方药的处方频率，从日本医疗数据中心（东京，日本）提取了2005年1月至2016年8月期间选定母亲在门诊和住院期间所开汉方药的信息，该中心是一个大型理赔数据库。从数据库中识别出的33,941名订阅者中，16,294人（48%）至少接受过一次汉方药处方。在研究期间，葛根汤是处方最多的方剂，其次是小柴胡汤和当归芍药散。在怀孕前180天，处方最多的药物是当归芍药散，其次是葛根汤和小柴胡汤。小柴胡汤、当归芍药散和葛根汤是孕期处方最多的方剂。产后180天内处方最多的药物是葛根汤、小柴胡汤和柴苓汤。日本保险系统的信息显示，汉方药在孕期经常被处方。这些处方大多通常用于治疗普通感冒。尤其是当归芍药散通常用于治疗孕期的各种症状。需要进一步研究以阐明日本孕期使用汉方药与婴儿不良事件之间的关系。
