Haque A, Lucas B, Hober D
Chercheur au CNRS, Dartmouth medical school, One Medical Center Drive, Rubin Bldg., Lebanon, NH 03756, Etats-Unis.
Ann Biol Clin (Paris). 2007 Mar-Apr;65(2):125-33.
This review emphasizes the need to improve the knowledge of the biology of H5N1 virus, a candidate for causing the next influenza pandemic. In-depth knowledge of mode of infection, mechanisms of pathogenesis and immune response will help in devising an efficient and practical control strategy against this flu virus. We have discussed limitations of currently available vaccines and proposed novel approaches for making better vaccines against H5N1 influenza virus. They include cell-culture system, reverse genetics, adjuvant development. Our review has also underscored the concept of therapeutic vaccine (anti-disease vaccine), which is aimed at diminishing 'cytokine storm' seen in acute respiratory distress syndrome and/or hemophagocytosis.
本综述强调了提高对H5N1病毒生物学知识的必要性，该病毒是引发下一次流感大流行的候选病毒。深入了解感染模式、发病机制和免疫反应，将有助于制定针对这种流感病毒的有效且实用的控制策略。我们讨论了现有疫苗的局限性，并提出了制备更好的抗H5N1流感病毒疫苗的新方法。这些方法包括细胞培养系统、反向遗传学、佐剂研发。我们的综述还强调了治疗性疫苗（抗病疫苗）的概念，其旨在减轻急性呼吸窘迫综合征和/或噬血细胞综合征中出现的“细胞因子风暴”。
