Harada Katsuhisa, Noguchi Tsuyoshi, Fujiwara Shozo, Moriyama Hatsuo, Kitano Seigo, Kawahara Katsunobu
Dept. of Surgery II, Oita University of Medicine.
Gan To Kagaku Ryoho. 2007 Mar;34(3):427-30.
The patient was an 80-year-old man whose complaint was coffee-grounds vomit. He was diagnosed with advanced gastric cancer, T2N1H0P0M0, stage II. Though the curative operation was explained to the patient, he declined it because of complications of advanced age, diabetes and bronchial asthma; chemotherapy was chosen instead. TS-1 (80 mg/day) was administered for 28 days, followed by 14 days rest as one course. A partial response was observed after the first course, and no cancer cells were confirmed by endoscopic biopsy after the fifth course. Moreover, after the 14th course, CT showed a complete regression of lymph node metastasis, and no cancer cells were confirmed by endoscopic biopsy, for a complete response (CR). From now on, as society grays more and more, it is considered that elderly advanced gastric cancer patients with complications will increase. TS-1 single treatment is considered to be safe and outpatient treatment possible as one of the useful cures.
该患者为一名80岁男性，主诉为咖啡渣样呕吐物。他被诊断为晚期胃癌，T2N1H0P0M0，II期。尽管向患者解释了根治性手术，但由于高龄、糖尿病和支气管哮喘并发症，他拒绝了手术；转而选择化疗。给予替吉奥（TS-1，80毫克/天），持续28天，随后休息14天作为一个疗程。第一个疗程后观察到部分缓解，第五个疗程后内镜活检未发现癌细胞。此外，第14个疗程后，CT显示淋巴结转移完全消退，内镜活检未发现癌细胞，达到完全缓解（CR）。今后，随着社会老龄化程度越来越高，预计伴有并发症的老年晚期胃癌患者将会增加。作为有效的治疗方法之一，TS-1单药治疗被认为是安全的，且可门诊治疗。
