Koshiba Takaaki, Ito Atsushi, Li Ying, Wu Yanling, Takemura Mami, Sakaguchi Shimon
Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University.
Nihon Rinsho. 2007 Mar;65(3):557-67.
Tolerance after clinical transplantation (Tx) is still extremely rare. However, Kyoto elective protocol enabled a substantial number of patients to weaned off immunosuppression after liver Tx. This is referred to as an immunoprivilege. Nevertheless, the operating mechanisms for liver Tx tolerance remain elusive. The authors demonstrated that regulatory T cells (Tregs) are likely to play an important role in liver Tx tolerance. In addition, we found that precursor like Tregs exist in the human peripheral blood. This can propagate upon stimulation with allo-antigen, in contrast to anergic property of Tregs. Thus, the exploitation of precursor like Tregs as a cellular source of ex vivo and in vivo expansion may lead to the widespread clinical use of Tregs for Tx.
临床移植（Tx）后的耐受情况仍然极为罕见。然而，京都择期方案使大量肝移植患者在移植后能够停用免疫抑制药物。这被称为免疫特惠。尽管如此，肝移植耐受的作用机制仍不清楚。作者证明调节性T细胞（Tregs）可能在肝移植耐受中发挥重要作用。此外，我们发现人类外周血中存在前体样调节性T细胞。与调节性T细胞的无反应特性相反，这种细胞在同种异体抗原刺激下可增殖。因此，利用前体样调节性T细胞作为体内外扩增的细胞来源可能会使调节性T细胞在移植中得到广泛的临床应用。
