沙眼衣原体C血清型复合体是早产的一个危险因素。

Chlamydia trachomatis C-complex serovars are a risk factor for preterm birth.

作者信息

Hollegaard Stine, Vogel Ida, Thorsen Poul, Jensen Inge Panum, Mordhorst Carl-Heinrich, Jeune Bernard

机构信息

NANEA, Department of Epidemiology, Institute of Public Health, University of Aarhus, 8000 Aarhus C, Denmark.

出版信息

In Vivo. 2007 Jan-Feb;21(1):107-12.

PMID:17354622

Abstract

BACKGROUND

Potential associations between current or previous C. trachomatis infections (general IgG and serovars) and spontaneous preterm birth (PTB) were examined and associations between C. trachomatis infections and previous fertility problems were explored.

PATIENTS AND METHODS

At week 17, Chlamydia antigen, Chlamydia IgG, Chlamydia complex B, C and GF levels were measured. Spontaneous preterm birth (< 37 completed weeks gestation) was the primary outcome, and secondary outcomes included infertility treatment, subfertility and ectopic pregnancies. Crude and adjusted relative risks (RR) and odds ratios (OR) were estimated by logistic regression.

RESULTS

C. trachomatis C-complex positivity was associated with spontaneous PTB [RR 2.6 (1.1-6.29)] and additionally with a prior history of subfertility [OR 4.4 [2.5-7.7]), infertility treatment [OR 7.2 (4.0-12.8)] and ectopic pregnancy [5.2 (2.2-12.4)].

CONCLUSION

A previous infection with C. trachomatis C-complex was associated with an increased risk for spontaneous PTB and may potentially contribute to subfertility, infertility and ectopic pregnancy.

摘要