Boctor Emad, deOliveira Michelle, Choti Michael, Ghanem Roger, Taylor Russell, Hager Gregory, Fichtinger Gabor
Engineering Research Center, Johns Hopkins University, Baltimore, MD, USA.
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):405-12. doi: 10.1007/11866763_50.
A rapid approach to monitor ablative therapy through optimizing shape and elasticity parameters is introduced. Our motivating clinical application is targeting and intraoperative monitoring of hepatic tumor thermal ablation, but the method translates to the generic problem of encapsulated stiff masses (solid organs, tumors, ablated lesions, etc.) in ultrasound imaging. The approach involves the integration of the following components: a biomechanical computational model of the tissue, a correlation approach to estimate/track tissue deformation, and an optimization method to solve the inverse problem and recover the shape parameters in the volume of interest. Successful convergence and reliability studies were conducted on simulated data. Then ex-vivo studies were performed on 18 ex-vivo bovine liver samples previously ablated under ultrasound monitoring in controlled laboratory environment. While B-mode ultrasound does not clearly identify the development of necrotic lesions, the proposed technique can potentially segment the ablation zone. The same framework can also yield both partial and full elasticity reconstruction.
介绍了一种通过优化形状和弹性参数来监测消融治疗的快速方法。我们具有启发性的临床应用是针对肝脏肿瘤热消融的靶向和术中监测，但该方法可转化为超声成像中包封的硬肿块（实体器官、肿瘤、消融病变等）的一般问题。该方法涉及以下组件的整合：组织的生物力学计算模型、估计/跟踪组织变形的相关方法以及解决逆问题并恢复感兴趣体积中的形状参数的优化方法。对模拟数据进行了成功的收敛性和可靠性研究。然后，在受控实验室环境中，对18个先前在超声监测下进行消融的离体牛肝样本进行了离体研究。虽然B模式超声不能清楚地识别坏死病变的发展，但所提出的技术有可能分割消融区。相同的框架还可以进行部分和全弹性重建。
