Taboada Elena, Rodríguez Elisenda, Roig Anna, Oró Judit, Roch Alain, Muller Robert N
Institut de Ciència de Materials de Barcelona, Consejo Superior de Investigaciones Científicas (ICMAB-CSIC), Esfera de la UAB, 08193 Bellaterra, Catalunya, Spain.
Langmuir. 2007 Apr 10;23(8):4583-8. doi: 10.1021/la063415s. Epub 2007 Mar 14.
Here we report on the synthesis of ultrasmall gamma-Fe2O3 nanoparticles (5 nm) presenting a very narrow particle size distribution and an exceptionally high saturation magnetization. The synthesis has been carried out by decomposition of an iron organometallic precursor in an organic medium. The particles were subsequently stabilized in an aqueous solution at physiological pH, and the colloidal dispersions have been thoroughly characterized by complementary techniques. Particular attention has been given to the assessment of the mean particle size by transmission electron microscopy, X-ray diffraction, dynamic light scattering, magnetic, and relaxometric measurements. The good agreement found between the different techniques points to a very narrow particle size distribution. Regarding the magnetic properties, the particles are superparamagnetic at room temperature and present an unusually high saturation magnetization value. In addition, we describe the potential of these particles as specific positive contrast agents for magnetic resonance molecular imaging.
在此，我们报道了超小γ-Fe2O3纳米颗粒（5纳米）的合成，其呈现出非常窄的粒径分布和异常高的饱和磁化强度。合成是通过在有机介质中分解有机金属铁前驱体进行的。随后，这些颗粒在生理pH值的水溶液中得以稳定，并且通过互补技术对胶体分散体进行了全面表征。通过透射电子显微镜、X射线衍射、动态光散射、磁性和弛豫测量等技术对平均粒径的评估给予了特别关注。不同技术之间的良好一致性表明粒径分布非常窄。关于磁性，这些颗粒在室温下是超顺磁性的，并且呈现出异常高的饱和磁化强度值。此外，我们描述了这些颗粒作为磁共振分子成像的特异性阳性对比剂的潜力。
