Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Phys Chem Chem Phys. 2012 Feb 28;14(8):2631-6. doi: 10.1039/c2cp23196d. Epub 2012 Jan 25.
Using an improved hydrolysis method of inorganic salts assisted with water-bath incubation, ultrasmall water-soluble metal-iron oxide nanoparticles (including Fe(3)O(4), ZnFe(2)O(4) and NiFe(2)O(4) nanoparticles) were synthesized in aqueous solutions, which were used as T(1)-weighted contrast agents for magnetic resonance imaging (MRI). The morphology, structure, MRI relaxation properties and cytotoxicity of the as-prepared metal-iron oxide nanoparticles were characterized, respectively. The results showed that the average sizes of nanoparticles were about 4 nm, 4 nm and 5 nm for Fe(3)O(4), ZnFe(2)O(4) and NiFe(2)O(4) nanoparticles, respectively. Moreover, the nanoparticles have good water dispersibility and low cytotoxicity. The MRI test showed the strong T(1)-weighted, but the weak T(2)-weighted MRI performance of metal-iron oxide nanoparticles. The high T(1)-weighted MRI performance can be attributed to the ultrasmall size of metal-iron oxide nanoparticles. Therefore, the as-prepared metal-iron oxide nanoparticles with good water dispersibility and ultrasmall size can have potential applications as T(1)-weighted contrast agent materials for MRI.
采用改进的无机盐水相辅助水浴孵化水解法，在水溶液中合成了超小水溶性金属-铁氧化物纳米粒子（包括 Fe(3)O(4)、ZnFe(2)O(4) 和 NiFe(2)O(4)纳米粒子），用作磁共振成像（MRI）的 T(1)加权造影剂。分别对所制备的金属-铁氧化物纳米粒子的形貌、结构、磁共振弛豫性能和细胞毒性进行了表征。结果表明，Fe(3)O(4)、ZnFe(2)O(4)和 NiFe(2)O(4)纳米粒子的平均粒径分别约为 4nm、4nm 和 5nm。此外，纳米粒子具有良好的水分散性和低细胞毒性。MRI 测试表明，金属-铁氧化物纳米粒子具有较强的 T(1)加权，但较弱的 T(2)加权 MRI 性能。高 T(1)加权 MRI 性能归因于金属-铁氧化物纳米粒子的超小尺寸。因此，所制备的具有良好水分散性和超小尺寸的金属-铁氧化物纳米粒子有望作为 MRI 的 T(1)加权造影剂材料得到应用。
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