Galindo-Moreno Pablo, Avila Gustavo, Fernández-Barbero Juan Emilio, Aguilar Mariano, Sánchez-Fernández Elena, Cutando Antonio, Wang Hom-Lay
Oral Surgery Department, School of Dentistry, University of Granada, Granada, Spain.
Clin Oral Implants Res. 2007 Jun;18(3):376-82. doi: 10.1111/j.1600-0501.2007.01337.x. Epub 2007 Mar 12.
The performance of implant surgery in the posterior maxilla often poses a challenge due to insufficient available bone. Sinus floor elevation was developed to increase needed vertical height to overcome this problem. The present study described and reported a simple, safe and predictable bone graft mixture for the sinus lifting procedure.
Seventy patients were recruited for this study and underwent a sinus lift procedure. All sites were treated with a composite graft of cortical autogenous bone, bovine bone and platelet-rich plasma (PRP). A total of 263 implants (171 Astra Tech and 92 Microdent) were placed either simultaneously or delayed. All sites were clinically and radiographically evaluated 24 months after their prosthetic loading. Biopsy samples were taken from 16 delayed implant placement sites at the time of their implant placement.
A 100% implant success rate was found after 24 months of functioning. Only two Microdent implants failed before loading, which translates to a 99% overall implant success rate. No statistically significant differences were found between simultaneous and delayed implant placement. Image processing revealed 34+/-6.34% vital bone, 49.6+/-6.04% connective tissue and 16.4+/-3.23% remaining Bio-Oss particles. However, the histomorphometric analysis showed that the bovine bone was incorporated into new bone formation.
The results showed that a composite graft comprised of cortical autogenous bone, bovine bone and PRP mixture can be successfully used for sinus augmentation.
由于上颌后牙区可用骨量不足，种植手术的实施常常面临挑战。上颌窦底提升术应运而生，以增加所需的垂直骨高度来克服这一问题。本研究描述并报告了一种用于上颌窦提升术的简单、安全且可预测的骨移植混合物。
本研究招募了70名患者并对其进行上颌窦提升手术。所有手术部位均采用皮质自体骨、牛骨和富血小板血浆（PRP）的复合移植材料进行治疗。总共植入了263颗种植体（171颗Astra Tech种植体和92颗Microdent种植体），植入方式为同期或延期植入。所有手术部位在义齿加载后24个月进行临床和影像学评估。在16个延期种植部位植入种植体时采集活检样本。
经过24个月的功能观察，种植成功率达100%。仅有2颗Microdent种植体在加载前失败，总体种植成功率为99%。同期和延期种植之间未发现统计学上的显著差异。图像处理显示，有活力的骨组织占34±6.34%，结缔组织占49.6±6.04%，剩余的Bio - Oss颗粒占16.4±3.23%。然而，组织形态计量学分析表明牛骨已融入新骨形成过程。
结果表明，由皮质自体骨、牛骨和PRP混合物组成的复合移植材料可成功用于上颌窦增量手术。
