Zucman David, Truchis Pierre de, Majerholc Catherine, Stegman Sophia, Caillat-Zucman Sophie
Réseau Ville-Hopital Val de Seine, Hopital Foch, Suresnes, France.
J Acquir Immune Defic Syndr. 2007 May 1;45(1):1-3. doi: 10.1097/QAI.0b013e318046ea31.
The association of human leukocyte antigen-B5701 with abacavir hypersensitivity varies depending on ethnic origin. We confirmed the high specificity of B5701 in the ethnically mixed French population and used a rapid and inexpensive polymerase chain reaction strategy to evaluate the predictiveness of B*5701 screening. The incidence of hypersensitivity decreased from 12% before screening to 0% after screening, and the rate of unwarranted interruptions of abacavir therapy decreased from 10.2% to 0.73%. We therefore recommend the implementation of this cost-effective screen before treatment with abacavir.
人类白细胞抗原-B5701与阿巴卡韦超敏反应的关联因种族起源而异。我们在种族混合的法国人群中证实了B5701的高特异性，并采用快速且经济的聚合酶链反应策略来评估B*5701筛查的预测性。超敏反应的发生率从筛查前的12%降至筛查后的0%，阿巴卡韦治疗不必要中断的比率从10.2%降至0.73%。因此，我们建议在使用阿巴卡韦治疗前实施这种具有成本效益的筛查。
