Belfi C A, Ting L L, Hassenbusch S J, Tefft M, Ngo F Q
Cleveland Clinic Foundation, OH 44195.
Int J Radiat Oncol Biol Phys. 1992;22(3):477-82. doi: 10.1016/0360-3016(92)90857-e.
Magnetic resonance imaging, using the paramagnetic chelate gadopentetate dimeglumine as a perfusing agent, was used to investigate the effect of the vasoactive drug hydralazine on tumor blood perfusion. The method requires measurements of the magnetic resonance image intensity changes with time on a pre-selected region of interest in the tumor image, immediately following intravenous injection of gadopentetate dimeglumine. The present study showed that the initial slope of the intensity-time curve can be used, to a first approximation, to infer tumor blood perfusion. With the dynamic imaging technique, it was demonstrated that, in the KHT sarcoma implanted intramuscularly in the hind leg of C3H/HeN mice, intraperitoneal administration of hydralazine reduced the volume-averaged tumor blood perfusion in a dose-dependent manner. The intrinsically high spatial resolution of magnetic resonance imaging allows a detailed study of the heterogeneous nature of tumor blood perfusion. The potential applications of this imaging technique to study the differential effects of hydralazine on perfusion between tumor and normal tissues will be discussed. The clinical utility of the technique should be promising because of its non-invasive nature.
利用顺磁性螯合物钆喷酸葡胺作为灌注剂的磁共振成像技术，被用于研究血管活性药物肼苯哒嗪对肿瘤血液灌注的影响。该方法要求在静脉注射钆喷酸葡胺后，立即在肿瘤图像上预先选定的感兴趣区域测量磁共振图像强度随时间的变化。本研究表明，强度 - 时间曲线的初始斜率在一阶近似下可用于推断肿瘤血液灌注。通过动态成像技术证实，在C3H/HeN小鼠后腿肌肉内植入的KHT肉瘤中，腹腔注射肼苯哒嗪以剂量依赖的方式降低了体积平均肿瘤血液灌注。磁共振成像固有的高空间分辨率允许对肿瘤血液灌注的异质性进行详细研究。将讨论这种成像技术在研究肼苯哒嗪对肿瘤组织和正常组织灌注的差异效应方面的潜在应用。由于其非侵入性，该技术的临床应用前景应该很广阔。
