Guzowski A, Gacko M, Worowska A, Kowalewski R, Ostapowicz R, Ploński A
Department of Vascular Surgery and Transplantology, Medical University of Białystok, Poland.
Adv Med Sci. 2006;51:205-7.
Behaviour of the vein thrombus is determined by the activity ratio of coagulation factors to factors of fibrinolytic system. The aim of the study is to evaluate activity of some coagulation and fibrinolytic factors in the vein thrombus.
The activity of platelets aggregating factors, tissue factor, thrombin, antithrombins, antiheparin factors, plasminogen activators, plasmin (plasminogen) and antiplasmins of the vein thrombus homogenate was determined using coagulative, fibrinolytic and caseinolytic tests. Retracted blood clot was a compared material.
Tissue factor activity in the vein thrombus was above twofold higher and antiheparin activity was nearly twice higher in comparison to the blood clot. The vein thrombus contains also active thrombin. Plasminogen activators activity in the vein thrombus was twofold higher and activity of plasmin (plasminogen) was threefold higher than in the blood clot. High activity of the tissue factor, substances neutralizing heparin and presence of thrombin intensify the thrombus enlargement. However, the thrombotic tendency may be balanced by a high activity of plasminogen activators and high activity of plasmin (plasminogen).
静脉血栓的行为由凝血因子与纤维蛋白溶解系统因子的活性比决定。本研究的目的是评估静脉血栓中一些凝血和纤维蛋白溶解因子的活性。
采用凝血、纤维蛋白溶解和酪蛋白溶解试验，测定静脉血栓匀浆中血小板聚集因子、组织因子、凝血酶、抗凝血酶、抗肝素因子、纤溶酶原激活剂、纤溶酶（纤溶酶原）和抗纤溶酶的活性。回缩的血凝块作为对照材料。
与血凝块相比，静脉血栓中的组织因子活性高出两倍多，抗肝素活性高出近两倍。静脉血栓中还含有活性凝血酶。静脉血栓中的纤溶酶原激活剂活性比血凝块高出两倍，纤溶酶（纤溶酶原）活性高出三倍。组织因子的高活性、中和肝素的物质以及凝血酶的存在会加剧血栓的增大。然而，纤溶酶原激活剂的高活性和纤溶酶（纤溶酶原）的高活性可能会平衡血栓形成倾向。
1）静脉血栓的特征是组织因子活性高、存在活性凝血酶和抗肝素活性高。2）静脉血栓的高凝血潜能在一定程度上被高纤维蛋白溶解潜能所平衡：纤溶酶原激活剂的高活性和纤溶酶（纤溶酶原）的高活性，以及抗纤溶酶活性的缺乏。
