Gacko M, Worowska A, Głowiński S
Department of Vascular Surgery and Transplantology, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1999;44:102-10.
Lumen of aortic aneurysm is usually filled with parietal thrombus. Behaviour of the parietal thrombus is determined by the ratio of coagulation factors to factors of fibrinolytic system. Activity of some factors of coagulation and fibrinolysis in the parietal thrombus of aortic aneurysm was determined using coagulative, fibrinolytic and caseinolytic tests. Retracted, blood clot was a comparative material. Tissue factor activity in the parietal thrombus of the aneurysm was above threefold higher and antiheparin activity was nearly twice higher in comparison to the blood clot. Activity of plasminogen activators in the parietal thrombus was higher than in the blood clot. The parietal thrombus contained fourfold more of the plasminogen. Antiplasmin activity in the thrombus was above twofold lower than in the blood clot. High activity of the tissue factor and substances neutralizing heparin may intensify the thrombus growth. Yet the thrombotic tendency may be balanced by a high activity of plasminogen activators and plasminogen.
主动脉瘤管腔通常充满壁内血栓。壁内血栓的形成取决于凝血因子与纤维蛋白溶解系统因子的比例。采用凝血、纤维蛋白溶解和酪蛋白溶解试验测定主动脉瘤壁内血栓中某些凝血和纤维蛋白溶解因子的活性。回缩的血凝块作为对照材料。与血凝块相比，动脉瘤壁内血栓中的组织因子活性高出三倍以上，抗肝素活性高出近两倍。壁内血栓中纤溶酶原激活剂的活性高于血凝块。壁内血栓中的纤溶酶原含量多出四倍。血栓中的抗纤溶酶活性比血凝块低两倍以上。组织因子和中和肝素物质的高活性可能会加剧血栓生长。然而，纤溶酶原激活剂和纤溶酶原的高活性可能会平衡血栓形成倾向。
