Hu Jiankun, Chen Xinzu, Zhou Zongguang
Department of General Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Feb;21(2):175-9.
To review the development of researches on the stem cells and the tissue engineering technique used in the intestines.
We comprehensively reviewed the literature related to the stem cells and the tissue engineering technique used in the intestines, and summarized the conclusions made by the researches concerned.
The researches on the stem cells and the tissue engineering technique used in the intestines were attractive topics in the recent years and obtained some developments, especially in the field dealing with the characteristics, proliferation and differentiation of the intestinal stem cells as well as the tissue engineering framework of the small intestinal submucosa in vivo. However, the markers for the differentiation of the intestinal stem cells were still a critical problem, which had not been solved yet, and besides, the researches on the intestinal tissue engineering were still in the initial stage.
There is a broad prospective application of the intestinal stem cells and the tissue engineering technique to the intestinal problem solution. Substantial achievements can be obtained in the treatment of the inflammatory bowel disease, in an exploration on the oncogenesis mechanism, and in the clinical application of the intestinal tissue engineering.
回顾干细胞及用于肠道的组织工程技术的研究进展。
全面检索与用于肠道的干细胞及组织工程技术相关的文献，并总结相关研究得出的结论。
近年来，用于肠道的干细胞及组织工程技术研究是热门课题并取得了一些进展，尤其是在肠道干细胞的特性、增殖与分化以及小肠黏膜下层组织工程支架的体内研究方面。然而，肠道干细胞分化的标志物仍是一个尚未解决的关键问题，此外，肠道组织工程研究仍处于初始阶段。
肠道干细胞及组织工程技术在解决肠道问题方面具有广阔的应用前景。在炎症性肠病的治疗、肿瘤发生机制的探索以及肠道组织工程的临床应用中有望取得丰硕成果。
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