Gomillion Cheryl T, Burg Karen J L
Department of Bioengineering, 501 Rhodes Engineering Research Center, Clemson University, Clemson, SC 29634, USA.
Biomaterials. 2006 Dec;27(36):6052-63. doi: 10.1016/j.biomaterials.2006.07.033. Epub 2006 Sep 14.
A large proportion of the plastic and reconstructive surgical procedures performed each year are to repair soft tissue defects that result from traumatic injury, tumor resection, and congenital defects. These defects typically result from the loss of a large volume of adipose tissue. To date, no ideal filler material which is successful in all cases has been developed. Additionally, the success of using autologous fat tissue grafts to repair soft tissue defects has been limited. Researchers are thus investigating strategies to engineer volumes of adipose tissue that may be used in these cases. A necessary component for engineering a viable tissue construct is an appropriate cell source. Attempts to engineer adipose tissue have involved the use of preadipocytes and adipocytes as the base cell source. Increased interest surrounding the research and development of stem cells as a source of cells for tissue engineering has, however, led to a new path of investigation for developing adipose tissue-engineering strategies. This manuscript serves as a review of the current state of adipose tissue-engineering methods and describes the shift toward tissue-engineering strategies using stem cells.
每年进行的大量整形和重建外科手术都是为了修复因创伤性损伤、肿瘤切除和先天性缺陷导致的软组织缺损。这些缺损通常是由于大量脂肪组织的缺失造成的。迄今为止，尚未开发出在所有情况下都能成功的理想填充材料。此外，使用自体脂肪组织移植修复软组织缺损的成功率也很有限。因此，研究人员正在研究能够构建可用于这些情况的脂肪组织的策略。构建有活力的组织构建体的一个必要组成部分是合适的细胞来源。尝试构建脂肪组织涉及使用前脂肪细胞和脂肪细胞作为基础细胞来源。然而，随着围绕干细胞作为组织工程细胞来源的研究和开发的兴趣增加，为开发脂肪组织工程策略开辟了一条新的研究途径。本文献对脂肪组织工程方法的当前状态进行了综述，并描述了向使用干细胞的组织工程策略的转变。
