Papp Maria, Lakatos Peter Laszlo, Palatka Karoly, Foldi Ildiko, Udvardy Miklos, Harsfalvi Jolan, Tornai Istvan, Vitalis Zsuzsanna, Dinya Tamas, Kovacs Agota, Molnar Tamas, Demeter Pal, Papp Janos, Lakatos Laszlo, Altorjay Istvan
Department of Gastroenterology, University of Debrecen, Nagyerdei krt. 98, H-4012, Debrecen, Hungary.
Dig Dis Sci. 2007 May;52(5):1279-84. doi: 10.1007/s10620-006-9615-1. Epub 2007 Mar 15.
Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp(1) allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp(2-1) vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.
发现与三种主要的触珠蛋白（Hp）表型相关的功能差异及其与炎症性疾病的关联。我们的目的是研究匈牙利克罗恩病（CD）患者的Hp多态性。对468例CD患者和384例健康对照进行了检查。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳和血清免疫印迹法确定Hp表型。与对照组（0.345）相比，CD患者中Hp(1)等位基因的频率显著更高（0.395；比值比，1.24；95%置信区间，1.02 - 1.52；P = 0.03）。在CD患者中，Hp表型与疾病行为相关（比值比[Hp(2-1)与其他表型相比]，2.06；95%置信区间，1.29 - 3.28，针对炎症行为）。此外，与Hp 1-1表型相比，Hp 2-2表型的原发性硬化性胆管炎发生率增加（6.5%对0.0%；P = 0.039）。我们得出结论，在匈牙利患者中，Hp多态性与CD、炎症性疾病行为和原发性硬化性胆管炎相关。需要进一步研究以评估Hp多态性在来自不同地理区域的其他人群中的意义。
