Philipson B, Fagerholm P, Calel B, Grunge A
Department of Ophthalmology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
J Cataract Refract Surg. 1992 Jan;18(1):71-8. doi: 10.1016/s0886-3350(13)80386-0.
Two types of intraocular lenses (IOLs) were used in a controlled, randomized, double-masked clinical trial. The study lens was a one-piece, poly(methyl methacrylate) (PMMA) lens with heparin grafted on the entire surface. The control lens was identical in all respects but lacked the heparin surface. The IOLs were implanted in the capsular bag after extracapsular cataract extraction in 266 patients. No unexpected reactions or severe complications occurred. The postoperative visual acuity of all cases at the three-month visit was 20/40 or better in 91.6% of the heparin group and in 86.2% of the control group. When excluding cases with preoperative pathology, 97% of the heparin group and 95% of the control group had a visual acuity of 20/40 or better. A mild iritis was observed in one case of the heparin group and in four cases of the control group at three months. At three months there was a statistically significant difference between the heparin surface modified and control IOLs for both the number of patients with cellular precipitates and the number of precipitates per IOL. From the present data we conclude that during the first three postoperative months heparin surface modified lenses are more biocompatible than PMMA lenses.
在一项对照、随机、双盲临床试验中使用了两种类型的人工晶状体（IOL）。研究用晶状体是一种一体式聚甲基丙烯酸甲酯（PMMA）晶状体，其整个表面接枝了肝素。对照晶状体在所有方面均相同，但没有肝素表面。在266例患者进行囊外白内障摘除术后，将IOL植入囊袋中。未发生意外反应或严重并发症。肝素组91.6%的患者和对照组86.2%的患者在术后三个月随访时所有病例的视力为20/40或更好。排除术前有病变的病例后，肝素组97%的患者和对照组95%的患者视力为20/40或更好。在三个月时，肝素组有1例患者、对照组有4例患者出现轻度虹膜炎。在三个月时，肝素表面改性IOL与对照IOL在细胞沉淀物患者数量和每个IOL的沉淀物数量方面存在统计学上的显著差异。根据目前的数据，我们得出结论，在术后的前三个月，肝素表面改性晶状体比PMMA晶状体具有更高的生物相容性。
