静脉排空对反应性充血血流反应的影响。
Influence of venous emptying on the reactive hyperemic blood flow response.
作者信息
Bahadir Zeki, Tisdell Eric, Arce Esquivel Arturo A, Dobrosielski Devon A, Welsch Michael A
机构信息
Department of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
出版信息
Dyn Med. 2007 Mar 14;6:3. doi: 10.1186/1476-5918-6-3.
BACKGROUND
Previous research indicates that venous emptying serves as a stimulus for vasodilation in the human forearm. This suggests the importance of recognizing the potential influence of venous volume on reactive hyperemic blood flow (RHBF) following occlusion. The purpose of this study was to examine the influence of venous emptying on forearm vascular function.
METHODS
Forearm RHBF, venous capacitance and venous outflow were examined in 35 individuals (age = 22 +/- 2 years), using mercury in-Silastic strain gauge plethysmography, at rest and following five minutes of upper arm occlusion using standard procedures (CONTROL). In addition, the same measures were obtained following five minutes of upper arm occlusion preceded by two minutes of passive arm elevation (Pre-elevation).
RESULTS
Average resting arterial inflow was 2.42 +/- 1.11 ml x 100 ml(-1) x min(-1). RHBF and venous capacitance were significantly greater during Pre-elevation compared to CONTROL (RHBF; Pre-elevation: 23.76 +/- 5.95 ml x 100 ml(-1) x min(-1) vs.
CONTROL
19.33 +/- 4.50; p = 0.001), (venous capacitance; Pre-elevation: 2.74 +/- 0.89 % vs.
CONTROL
2.19 +/- 0.97, p = 0.001). Venous outflow did not differ between the two conditions.
CONCLUSION
Venous emptying prior to upper arm occlusion results in a significant greater RHBF response and venous capacitance. Recognition of the influence of venous volume on RHBF is particularly important in studies focusing on arterial inflow, and also provides further evidence for the interplay between the venous and arterial system.
背景
先前的研究表明，静脉排空可作为人类前臂血管舒张的刺激因素。这表明认识到静脉容量对闭塞后反应性充血血流（RHBF）的潜在影响的重要性。本研究的目的是探讨静脉排空对前臂血管功能的影响。
方法
采用汞硅橡胶应变片体积描记法，对35名个体（年龄 = 22±2岁）在静息状态下以及按照标准程序进行上臂闭塞5分钟后（对照组），检测其前臂RHBF、静脉容量和静脉流出量。此外，在进行5分钟上臂闭塞前先进行2分钟被动手臂抬高（预抬高）后，再获得相同的测量值。
结果
平均静息动脉流入量为2.42±1.11 ml×100 ml⁻¹×min⁻¹。与对照组相比，预抬高期间的RHBF和静脉容量显著更大（RHBF；预抬高：23.76±5.95 ml×100 ml⁻¹×min⁻¹ 对 对照组：19.33±4.50；p = 0.001），（静脉容量；预抬高：2.74±0.89% 对 对照组：2.19±0.97，p = 0.001）。两种情况下静脉流出量无差异。
结论
上臂闭塞前的静脉排空导致显著更大的RHBF反应和静脉容量。认识到静脉容量对RHBF的影响在专注于动脉流入的研究中尤为重要，并且也为静脉和动脉系统之间的相互作用提供了进一步的证据。
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