He Qiang, Liang Li-jian, Shen Shun-li, Peng Bao-gang, Tang Di
Hepatobiliary Surgery Department, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Wai Ke Za Zhi. 2006 Dec 1;44(23):1617-9.
To retrospectively investigate the diagnosis and the outcome of Caroli's disease treated by surgical procedures.
The clinical data of 68 patients with Caroli's disease treated by surgical procedures between 1996 and 2002 were reviewed, retrospectively.
The patients, with a M/F ratio of 1:1.35 and a mean age of 46, presented mainly with recurrent cholangitis. Of all the patients, 26 had a history of operation for cholelithiasis or cholangitis. On admission, the image investigations suggested that the lesions located at left lobe in 44 patients, right lobe in 9 patients, and whole liver in 15 patients. The coexisting cyst in common bile duct was found in 20 patients. The malignant transformation was found in 5 patients (8.8%). Hepatectomy was performed in 82.4% of patients, with a morbidity rate of 15.0% and mortality rate of 0 after the surgery. The long-term outcome of symptom-free in hepatectomy group was 90.2%, significantly higher than the 33.3% in non-hepatectomy group (P < 0.01) after a 3 to 10 years of follow-up.
Hepatectomy offers a curative procedure for local Caroli's disease, and liver transplantation is a good option for diffuse sufferers.
回顾性研究手术治疗卡罗利病的诊断及预后情况。
回顾性分析1996年至2002年间接受手术治疗的68例卡罗利病患者的临床资料。
患者男女比例为1:1.35，平均年龄46岁，主要表现为复发性胆管炎。所有患者中，26例有胆囊结石或胆管炎手术史。入院时，影像学检查提示病变位于左叶44例，右叶9例，全肝15例。20例患者胆总管并存囊肿。5例（8.8%）发现恶变。82.4%的患者接受了肝切除术，术后发病率为15.0%，死亡率为0。肝切除组无症状的长期预后为90.2%，显著高于非肝切除组的33.3%（P<0.01），随访3至10年。
肝切除术为局限性卡罗利病提供了一种治愈性手术方法，肝移植是弥漫性患者的良好选择。
