Calderon Iracema M P, Damasceno Débora C, Amorin Renée L, Costa Roberto A A, Brasil Maria A M, Rudge Marilza V C
Diabetes and Pregnancy Service, Department of Gynecology & Obstetrics of Botucatu Medical School, Unesp, São Paulo, Brazil.
Diabetes Res Clin Pract. 2007 Oct;78(1):65-71. doi: 10.1016/j.diabres.2007.01.023. Epub 2007 Mar 13.
In this study, morphometric measures of placental terminal villi and villous vessels were compared in overt, as well as gestational diabetes mellitus, and mild hyperglycemia diagnosed by oral 100 g glucose tolerance test (100 g-OGTT) and glucose profile (GP). At delivery (gestational age> or =34 weeks) a total of 207 placentas were assigned to a control group (n=56) or to one of three groups complicated by mild hyperglycemia (n=51), gestational diabetes (n=59) and overt diabetes (n=41). Placenta samples were randomly selected for blind morphometric assessment with an image analyser. Morphometric measures obtained included area and number of terminal villi and their respective villous vessels. Statistical analyses were performed using the chi-square test, ANOVA and stepwise regression (p< or =0.05). Glycemic means were 86.2 mg/dL in controls, 98.9 mg/dL in mild hyperglycemia, 114.1 mg/dL in gestational diabetes and 122.1 mg/dL in overt diabetes. Our results show that abnormal maternal glycemic levels may change the placental morphometric characteristics related to materno-fetal exchanges.
在本研究中，对经口服100g葡萄糖耐量试验（100g-OGTT）和血糖监测（GP）诊断出的显性糖尿病、妊娠期糖尿病以及轻度高血糖孕妇的胎盘终末绒毛和绒毛血管进行了形态测量学比较。分娩时（孕周≥34周），共207个胎盘被分为对照组（n = 56）或合并轻度高血糖（n = 51）、妊娠期糖尿病（n = 59）和显性糖尿病（n = 41）的三组之一。随机选取胎盘样本，用图像分析仪进行盲法形态测量评估。获得的形态测量指标包括终末绒毛及其各自绒毛血管的面积和数量。采用卡方检验、方差分析和逐步回归进行统计分析（p≤0.05）。对照组血糖均值为86.2mg/dL，轻度高血糖组为98.9mg/dL，妊娠期糖尿病组为114.1mg/dL，显性糖尿病组为122.1mg/dL。我们的结果表明，孕妇血糖水平异常可能会改变与母婴物质交换相关的胎盘形态学特征。
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