Kitchener Scott, Nasveld Peter, Edstein Michael D
Centre for Military and Veterans Health, University of Queensland, Herston, Queensland, Australia.
Am J Trop Med Hyg. 2007 Mar;76(3):494-6.
Tafenoquine was used to treat Plasmodium vivax malaria cases who had previously failed treatment with chloroquine and primaquine. Chloroquine was followed by a loading dose of tafenoquine (200 mg base/day for 3 days) and 200 mg a week was given for 8 weeks. One of 27 treated patients relapsed after 6 months of observation. A standard course of chloroquine administered with 8 weeks of tafenoquine may be more effective than chloroquine with primaquine (22.5 mg/day for 14 days) in preventing additional P. vivax relapses. Larger studies are required to optimize the combination, but our findings suggest that an extended use of tafenoquine may be required to prevent relapses of primaquine-tolerant strains of P. vivax malaria.
他非诺喹被用于治疗先前氯喹和伯氨喹治疗失败的间日疟病例。氯喹之后给予负荷剂量的他非诺喹（200毫克碱基/天，共3天），随后每周给予200毫克，共8周。27例接受治疗的患者中有1例在观察6个月后复发。在预防间日疟再次复发方面，氯喹联合8周他非诺喹的标准疗程可能比氯喹联合伯氨喹（22.5毫克/天，共14天）更有效。需要开展更大规模的研究来优化这种联合用药方案，但我们的研究结果表明，可能需要延长他非诺喹的使用时间来预防对伯氨喹耐受的间日疟原虫株的复发。
